| Cell type (class) | Nomenclature (Acronym) |
Definition | Relation of photosensitive SCN-projecting retinal ganglion cell |
| Annotation | Reference |
Collator |
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| retinal ganglion cell type III | Perry (Perry) | Type III cells have small bodies but they have the largest range of dendritic field sizes (see table 1). The dendrites of this cell class branch less frequently than those of the other classes. This group of cells encompasses a slightly wider variety of dendritic morphology, than the other three classes. | is included | | Morphologically, these neurons fit the type III group fo rat RGCs (17), especially those shown to be intrinsically photosensitive (12). | Hattar S., Liao H.-W., Takao M., Berson D.M. & Yau K.-W. | Mihail Bota |
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| melanopsin-containing retinal ganglion cell | Berson, Hattar et al (BH) | Somatic immunoreactivity appeared mainly at the cell surface (Fig. 1B1), suggestive of melanopsin being targeted to the plasma membrane. Every labeled retinal cell was a ganglion cell, on the basis of the presence of an axon coursing into the optic fiber layer and toward the optic disc. More than 95% of labeled cell bodies were in ganglion cell layer, the remainder being dispalced to the inner nuclear layer. Dendrites from adjacent cells overlapped extensively, forming a reticular network (Fig. 1B2). The stained dendrites and proximal axons had a beaded appearance, showing punctate, dense labeling. The complete dendritic fields of labeled cells, visualized from stacked confocal images (e.g., Fig. 1B2). had varied sizes and shapes (Fig. 1C). Labeled displaced RGCs (Fig. 1C, right three cells) had similar soma sizes but less extensive dendritic arborizations than nondispalced cells (Fig. 1C, left three cells). The mean somatic diameter of labeld non-displaced RGCs was 16 micrometers (Fig 1.D), but the limited sample of dendritic-field measurements precluded any statistics. Morphologically, these neurons fit within the type III group of rat RGCs (17), especially tyose shown to be intrinsically photosensitive (12). ...Whether in the ganglion cell layer (Fig. 2A) or displaced to the inner nuclear layer (Fig. 2B), the melanopsin-expressing RGCs extended dendrites into the inner plexiform layer, where they arborized most extensively at the border with the inner nuclear layer. | partially corresponds | | The accompanying report (12) shows that RGCs projecting to the SCN are directly sensitive to the light. Collator note: the semantic relationship between these two cell populations is "partially corresponds" due to the lack of evidence that all light-sensitive RGCs project only to the suprachiasmatic nucleus, and to the lack of evidence that SCN receives retina input only from light-sensitive RGCs. | Hattar S., Liao H.-W., Takao M., Berson D.M. & Yau K.-W. | Mihail Bota |
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| SCN-projecting retinal ganglion cell | Moore (Moore) | Examination of whole mounts of a retina contralateral to the injected eye reveals a population of infected ganglion cells that appears to have a relatively uniform distribution across the retina. Individual neurosn have spherical-to-oval perikarya with two-to-four thin, sparsely branching proximal dendrites (Fig. 5). Dendrites extend radially from the cell soma, but the full extent of the dendritic arbors cannot be determined because the viral immunoreactivity does not extend into distal dendrites.... With Flurogold injections into the SCN that do not appear to extend into the optic chiasm, the labeled ganglion cells have a median area of 100 micrometers square. The mean area is 109.7 micrometers square and the mean diameter is 14.3 micrometers square. In addition ot the large numbers of small ganglion cells labeled there is a small number of larger cells with areas ranging from 160 to 250 micrometers square and diameters ranging from 18 to 22 micrometers. The data for the PRV injections in intact animals appear similar except that the median area (70 micrometers square), mediam diameter (12 micrometers), mean area (96.2 micrometers square) and mean diameter (13.7 micrometers) are all smaller than in the Fluorogold group. ...We interpret these differences to reflect that both the Fluorogold group and the intact PRV group are showing labeled ganglion cells that project to areas other than the SCN. | is included | | With Flurogold injections into the SCN that do not appear to extend into the optic chiasm, the labeled ganglion cells have a median area of 100 micrometers square. The mean area is 109.7 micrometers square and the mean diameter is 14.3 micrometers square. In addition ot the large numbers of small ganglion cells labeled there is a small number of larger cells with areas ranging from 160 to 250 micrometers square and diameters ranging from 18 to 22 micrometers. The data for the PRV injections in intact animals appear similar except that the median area (70 micrometers square), mediam diameter (12 micrometers), mean area (96.2 micrometers square) and mean diameter (13.7 micrometers) are all smaller than in the Fluorogold group. ... Collator note: retinal projections to the SCN are part of the RHT. | Moore R.Y., Speh J.C. & Card J.P. | Mihail Bota | | The accompanying report (12) shows that RGCs projecting to the SCN are directly sensitive to the light. Collator note: retinal projections to the SCN are part of the RHT. | Hattar S., Liao H.-W., Takao M., Berson D.M. & Yau K.-W. | Mihail Bota | |
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