| Cell type (class) | Nomenclature (Acronym) |
Definition | Relation of retinal ganglion cell type III |
| Annotation | Reference |
Collator |
| |
| melanopsin-containing retinal ganglion cell | Berson, Hattar et al (BH) | Somatic immunoreactivity appeared mainly at the cell surface (Fig. 1B1), suggestive of melanopsin being targeted to the plasma membrane. Every labeled retinal cell was a ganglion cell, on the basis of the presence of an axon coursing into the optic fiber layer and toward the optic disc. More than 95% of labeled cell bodies were in ganglion cell layer, the remainder being dispalced to the inner nuclear layer. Dendrites from adjacent cells overlapped extensively, forming a reticular network (Fig. 1B2). The stained dendrites and proximal axons had a beaded appearance, showing punctate, dense labeling. The complete dendritic fields of labeled cells, visualized from stacked confocal images (e.g., Fig. 1B2). had varied sizes and shapes (Fig. 1C). Labeled displaced RGCs (Fig. 1C, right three cells) had similar soma sizes but less extensive dendritic arborizations than nondispalced cells (Fig. 1C, left three cells). The mean somatic diameter of labeld non-displaced RGCs was 16 micrometers (Fig 1.D), but the limited sample of dendritic-field measurements precluded any statistics. Morphologically, these neurons fit within the type III group of rat RGCs (17), especially tyose shown to be intrinsically photosensitive (12). ...Whether in the ganglion cell layer (Fig. 2A) or displaced to the inner nuclear layer (Fig. 2B), the melanopsin-expressing RGCs extended dendrites into the inner plexiform layer, where they arborized most extensively at the border with the inner nuclear layer. | includes | | Morphologically, these neurons fit within the type III group of rat RGCs (17), especially tyose shown to be intrinsically photosensitive (12) | Hattar S., Liao H.-W., Takao M., Berson D.M. & Yau K.-W. | Mihail Bota |
|
| SCN-projecting retinal ganglion cell | Moore (Moore) | Examination of whole mounts of a retina contralateral to the injected eye reveals a population of infected ganglion cells that appears to have a relatively uniform distribution across the retina. Individual neurosn have spherical-to-oval perikarya with two-to-four thin, sparsely branching proximal dendrites (Fig. 5). Dendrites extend radially from the cell soma, but the full extent of the dendritic arbors cannot be determined because the viral immunoreactivity does not extend into distal dendrites.... With Flurogold injections into the SCN that do not appear to extend into the optic chiasm, the labeled ganglion cells have a median area of 100 micrometers square. The mean area is 109.7 micrometers square and the mean diameter is 14.3 micrometers square. In addition ot the large numbers of small ganglion cells labeled there is a small number of larger cells with areas ranging from 160 to 250 micrometers square and diameters ranging from 18 to 22 micrometers. The data for the PRV injections in intact animals appear similar except that the median area (70 micrometers square), mediam diameter (12 micrometers), mean area (96.2 micrometers square) and mean diameter (13.7 micrometers) are all smaller than in the Fluorogold group. ...We interpret these differences to reflect that both the Fluorogold group and the intact PRV group are showing labeled ganglion cells that project to areas other than the SCN. | includes | | The major group that is labeled in all of the experimental paradigms, SCN injection od FluoroGold and HRP and intravitreal PRV-Bartha injections, is the type III retinal ganglion cell (Perry, 1979; Dreher et al. 1985). | Moore R.Y., Speh J.C. & Card J.P. | Mihail Bota |
|
| retinal ganglion cell Class III | Dreher (Dreher) | Class III cells, have small to medium perikarya (6-20 micrometers) and large dendritic trees (up to 510 micrometers). The primary dendrites are fine and have only a few branches (fig. 1F), while the intraretinal axons of fine to medium calibre (0.3-0.8 micrometers in diameter; fig 3B). Although Class III cells project to the contralateral SC and DLG, as well as to the ipsilateral DLG, those projecting to SC tend to have smaller somata. | synonym | | Class III cells, like some of the Golgi-stained Type III cells distinguished by Perry [1979] or his HRP-labeled Type III cells [Perry, 1981], have small to medium perikarya (6-20 micrometers) and large dendritic trees (up to 510 micrometers). | Dreher B., Sefton A.J., Ni S.Y.K, Nisbett G. | Mihail Bota |
|
| photosensitive SCN-projecting retinal ganglion cell | Berson, Hattar et al (BH) | In isolated retinas, whole-cell recordings were made of the responses of labeled ganglion cells to light (10) (Fig. 1, A to E). In most of these cells (n = 150), light evoked large depolarizations with superimposed fast action potentials (Fig. 1, E to G) (11). Photosensitive ganglion cells shared a common morphology (Fig. 4, A and B), as revealed by intracellular staining with LY (28). Somata were intermediate in diameter among neurons of the ganglion cell layer (14.7 ± 1.2 micrometers,mean 6 SD; n= 18). Many cells sent an axon into the optic fiber layer; those lacking one had presumably lost it during mechanical exposure of the soma before recording. The sparsely branching, tortuous dendrites of these cells arborized primarily in the outer part (OFF sublayer)
of the inner plexiform layer (IPL; Fig. 4B). Although some dendrites coursed within the inner IPL (ON sublayer) for 100 to 200 micrometers, nearly all terminated in the OFF sublayer. Such stratification is highly unusual for ganglion cells depolarized by light [but see (29, 30)]. Dendritic fields were large (diameter 497 ± 115 micrometers; mean ± SD; n = 21). Stimuli illuminating the dendrites but not the soma consistently evoked light responses (31). | includes | | Morphologically, these neurons fit the type III group fo rat RGCs (17), especially those shown to be intrinsically photosensitive (12). | Hattar S., Liao H.-W., Takao M., Berson D.M. & Yau K.-W. | Mihail Bota |
|
| LHA-projecting retinal ganglion cell | Moore (Moore) | ...FluoroGold injections restricted to the LHA (n = 7) label a small population of cells found almost exclusively in one quadrant of the retina (Fig. 2). Although there is some variability in fiducial mark placementsm this appears to be the superior temporal quadrant of the retina. The size and morphology of these cells are consistent with the type III classification of Perry [24]. They have one to four thin radiating dendrites (Fig. 3A and B) which can be followed only for short distances, usually not more than a few cell diameters. Within these limits, the dendrites appaear to give off few branches. Retinas ipsilateral to LHA injections contain only a few labeled cells. The ipsilateral cells have a similar distribution and morphology. ...a homogenous population of cells with a mean area of 92.3 ± 23.3 micromenters2 and a mean diameter of 12.6 ± 1.6 micrometers. | includes | | The size and morphology of these cells are consistent with the type III classification of Perry [24]. | Leak R.H. & Moore R.Y. | Mihail Bota |
|
| retinal ganglion cell "loose" type | Brown-morphological (B-morpho) | In Fig. 3, cells A, C, E, and G are of the “tight” type, while B, D, and F are of the “loose” type. The dendritic trees of the loose type do not penetrate the internal plexiform layer as deeply as those of the tight type (Table 1 and Fig. 4). The loose-type
cells have fewer dendritic branches per main branch than the tight type (Table 1). the dendrites ramify (the “dendritic field”) may extend as much as 600-700 micrometers in the flat-mounted retina. The main dendrites of the loose type do not penetrate into the plexiform layer as steeply as do those of the tight type. The average size of dendritic field (Table 1) is 397 micrometers for loose-type cells and 282 micrometers for tight-type cells. | partial correspondence | | ...type III cells clearly correspond to some of the 'loose' ganglion cells described by Brown (1965)... | Perry V.H. | Mihail Bota |
|
| retinal ganglion cell C others | Huxlin and Goodchild (HG) | The Group RGc cells, as mentioned above, are a heterogeneous population: we labelled several neurons that could not be classified as RGC1 or RGC2. Includes previously described exmples of Type III or Class III cells (Perry, 1979, Dreher et al., 1985), with their small somata and, in some cases, very large dendritic fields. | is included | | Group RGC ‘‘others’’ includes previously described examples of Type III or Class III cells (Perry, 1979; Dreher et
al., 1985), with their small somata and, in some cases, very large dendritic fields. | Huxlin K.R & Goodchild A.K. | Mihail Bota |
|
| OP-projecting retinal ganglion cell | Young and Lund (YL) | Following unilateral OPN injections, labelled cells could be detected in both the ipsilateral and contralateral retinae. in the contralateral retina, the majority of Fluoro-Gold labeled cells were seen in the ventral hemiretina, inferior to the horizontal meridian. The majority of the remaining labeled cells were found in the nasal retinal quadrant, mostly in the peripheral and ventral portion of this quadrant. The diameter of labeled RGCs rangted from 7 micrometers to 25 micrometers. There appears to be two distinct populations of cells labeled, with the majority of cells in the smaller diameter group having the diameters ranging from 10-13 micrometers, and a less populous group of larger cells having diameters of 20-25 micrometers. | partially corresponds | | There appears to be two distinct populations of cells labeled, with the majority of cells in the smaller diameter group having the diameters ranging from 10-13 micrometers, and a less populous group of larger cells having diameters of 20-25 micrometers. Although the entire cell body apperead to be stained in nearly all of the labeled cells, very little dendritic morphology can be determined from this preparation. The average cell body size would suggest that the vast majority of these cells belong to class III. | Young M.J. & Lund R.D. | Mihail Bota |
|
